Xenical - a drug that blocks absorption of fats and is used for obesity. Xenical belongs to a group of drugs used in diseases of the gastrointestinal tract. The active substance Xenical - Orlistat.
The drug is prescribed as a long-term treatment of patients with obesity or patients with overweight, including those that are associated with obesity risk factors. Xenical is used in combination with antidiabetic drugs such as metformin, sulfonylurea drugs or insulin, or moderately hypocaloric diet in patients with diabetes mellitus type 2 with overweight or obese.
In addition to lowering blood lipids, which always arises because of weight loss, Xenical has its own, an additional positive effect on hyperlipidemia. As you know, cholesterol is poorly soluble in solutions of bile salts, and its solubility usually increases in direct proportion to the amount of free fatty acids and monoglycerides, which are there. Xenical reduces the amount of free fatty acids and monoglycerides in the intestinal lumen, inhibiting gastrointestinal lipases. This drug reduces the solubility and absorption of cholesterol. This reduces the absorption of non-polar lipids such as cholesterol.
Because Xenical partially inhibited hydrolysis and absorption of fats in the intestine, increases the amount of fat, which contacts the mucous membrane of the colon. While the role of a large intake of fats in the development of colon cancer is controversial. Therefore, the effect of Xenical has been studied on cell proliferation of the colon. It turned out that the drug has no effect on cell proliferation in biopsies of the colon, as had happened the correlation between changes in the composition of feces and the index of cell proliferation of the colon.
Basically Xenical is metabolized in the wall of the gastrointestinal tract. Adopted dose almost completely eliminated with the feces, with 83% eliminated as unchanged drug.
Sometimes, while taking the drug were observed phenomena such as oily separation from the rectum, imperative urge to defecate, gassing with some discharge, increased defecation and fecal incontinence, steatorrhea. But generally these side effects are mild. They can occur in the first three months, at an early stage of drug administration.
In addition, from the gastrointestinal tract may occur such undesirable phenomena as pain or abdominal discomfort, bloating, loose stools, soft stools, abdominal pain or discomfort in the rectum, the defeat of the teeth , damage to the gums.
The probability of side effects increases if the drug is accompanied by a rich intake from fat food, so the daily fat intake should be distributed in three main reception.
Xenical should be taken or during the meal or within 1 hour after ingestion of one capsule. If food is not too thick, you can not drink Xenical. Course of taking Xenical should not exceed two years.
Xenical is used against a moderately hypocaloric diet with fat content not exceeding 30%.During treatment Ksenikalom is to think carefully about your diet. satiate its fruit and vegetables. Chronic administration is also necessary to monitor the parameters of blood.
In addition, despite the fact that the concentration of vitamins in the course of treatment is the norm, it is recommended to take multivitamin complexes.


